SPAN-AMERICA ANNOUNCES SECOND QUARTER
CONFERENCE CALL ON THE INTERNET

GREENVILLE, S.C. – (April 21, 2006) – Span-America Medical Systems, Inc. (NASDAQ: SPAN) will provide an on-line, real-time webcast and rebroadcast of its second quarter conference call to be held on Thursday, April 27, 2006.

The live broadcast of Span-America's conference call will be available on-line at:

www.irinfo.com/span

or

www.investorcalendar.com

on Thursday, April 27, 2006, beginning at 10:00 a.m. ET. The on-line replay will follow immediately and continue for 30 days.

About Span-America Medical Systems, Inc.

Span-America manufactures and markets a comprehensive selection of pressure management products for the medical market, including Geo-Matt^®, PressureGuard^®, Geo-Mattress^®, Span+Aids^®, Isch-Dish^®, and Selan^® products. The Company also supplies custom foam and packaging products to the consumer and industrial markets. Span-America's stock is traded on The NASDAQ Stock Market's National Market under the symbol "SPAN."